Type & Frequency of Lymphomas: Single Institution Experience.

Objective: To see the type and frequency of lymphomas. Study Design: Prospective longitudinal study. Place and Duration of Study: Department of Medical Oncology at Jinnah Postgraduate Medical Centre, Karachi from Jan 2019 to Dec 2019. Methodology: Total of 150 patients with histopathological diagnoses of lymphoma of 17 to 71 years of age of either gender were included in the study using non-probability consecutive sampling technique. Prior to initiation of study ethics review committee has approved the study (NO.F.2-81-IRB/2019-GENL/10261/JPMC). The data regarding lymphoma type, histology, stage of disease, site, involvement of bone marrow, presence of B-symptoms were recorded. Results: Majority of the patients were male i.e., (n=104, 69.3%) with the mean age of 45.29±17.76 years. Non-Hodgkin's Lymphoma presented as the most common type of lymphoma i.e., (n=107, 71.3%) whereas Hodgkin's lymphoma (HL) contributed for (n=43, 28.7%) cases. Assessment of clinicopathological features of lymphomas revealed that (n=58, 38.7%) cases had bone marrow involvement. B-symptoms appeared in (n=102, 68%) cases, (n=61, 40.7%) cases were stage IV and the most common site were Neck lymph nodes (n=82, 58.3%), followed by abdomen (n=20, 13.3%). There was statistically significant difference between type of lymphoma with respect to age (p=0.001) and gender(p=0.015) Conclusion: Among lymphomas the most common type of lymphoma was Non-Hodgkin's Lymphoma, most common in patients >45 years of age showing relationship of its occurence with age and DLBCL is major subtype and among Hodgkin's lymphoma Classical type is the predominant type Epidemiologic characteristics and distribution of the disease varies with geographical region, racial & environmental factors. [ABSTRACT FROM AUTHOR]