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Preparation of polysaccharide-based nanoparticles by chitosan and flaxseed gum polyelectrolyte complexation as carriers for bighead carp (Aristichthys nobilis) peptide delivery.
- Source :
-
International Journal of Biological Macromolecules . Sep2023, Vol. 249, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- Polysaccharide-based nanoparticles formed by the polyelectrolyte complexation between chitosan (CS) and flaxseed gum (FG) was developed in this work, and it was further used as a carrier for bighead carp peptide (BCP) delivery. The CS molecular weight (M W) of 50 kDa and CS/FG mass ratio of 1:2 at pH 3.5 were optimal conditions for the NP preparation, with the minimum particle size (∼155.1 nm) and the maximum BCP encapsulation efficiency (60.3 %). The BCP-loaded CS/FG NPs exhibited the smallest particle size (175.8 nm). Both CS/FG NPs and CS/FG-BCP NPs exhibited roughly uniform spherical shape. FT-IR spectra confirmed the existence of hydrogen bonds and electrostatic interactions in the nanoparticles. The BCP-loaded NPs displayed a higher thermal stability than BCP. Moreover, the release of BCP was controllable and dose-dependent, following a first-order kinetics model. These findings suggested that our CS/FG NPs are a promising carrier for bioactive peptide delivery. Schematic diagram of preparation and structure of CS/FG-BCP NPs. [Display omitted] • Polysaccharide-based nanoparticles (NPs) were developed by chitosan (CS)-flaxseed gum (FG) complexation. • Bighead carp peptide (BCP)-loaded CS/FG NPs showed good thermal stability. • CS/FG NPs showed good protective effect on BCP functionalities. • CS/FG NPs are successfully applied for controlled release of BCP. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 249
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 172306187
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2023.126121