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Combined systemic inflammatory indexes as reflectors of outcome in patients with COVID‑19 infection admitted to ICU.
- Source :
-
Inflammopharmacology . Oct2023, Vol. 31 Issue 5, p2337-2348. 12p. - Publication Year :
- 2023
-
Abstract
- Introduction: The principal etiology of mortality in COVID-19 patients is the systemic pro-inflammatory processes which may lead to acute respiratory distress syndrome. Hematologic indices are reachable representatives of inflammation in patients with COVID-19 infection. The purpose of the current study was to evaluate the potential predictive value of these inflammatory indices in the in-hospital mortality of ICU-admitted COVID-19 patients. The studied indexes included AISI, dNLR, NLPR, NLR, SII, and SIRI. Method: 315 COVID-19 patients admitted to ICU managed in Imam Khomeini Hospital of Urmia, Iran, during the last 6 months of 2020 were retrospectively enrolled in the study and divided into two subgroups based on their final outcome, discharge or death. Results: Total leucocyte count (TLC), absolute neutrophil count (NLC), urea, Cr, RDW, AISI, dNLR, NLPR, NLR, SII, and SIRI were drastically elevated in the dead patients (P < 0.05). The optimal cut-off points for AISI (378.81), dNLR (5.66), NLPR (0.03), NLR (5.97), SII (1589.25), and SIRI (2.31) were obtained using ROC curves. NLR and SII had the highest sensitivity (71.4%) and specificity (73.6%), respectively. Patients with above-cut-off levels of ISI, dNLR, NLPR, NLR, and SII had lower average survival time. Age (OR = 1.057, CI95%: 1.030–1.085, p < 0.001) and dNLR (OR = 1.131, CI95%: 1.061–1.206, p < 0.001) were the independent predictors for mortality in the studied COVID-19 patients based on multivariate logistic regression. Conclusion: Age and dNLR are valuable predictive factors for in-hospital death of ICU-admitted COVID-19 patients. Besides, other indices, AISI, NLPR, NLR, SII, and SIRI, may have an additional role that requires further investigation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COVID-19
*ADULT respiratory distress syndrome
*HOSPITAL mortality
Subjects
Details
- Language :
- English
- ISSN :
- 09254692
- Volume :
- 31
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Inflammopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 172311866
- Full Text :
- https://doi.org/10.1007/s10787-023-01308-8