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Recent advances of drugs monitoring in oral fluid and comparison with blood.
- Source :
-
Clinical Chemistry & Laboratory Medicine . Oct2023, Vol. 61 Issue 11, p1978-1993. 16p. - Publication Year :
- 2023
-
Abstract
- The use of alternative matrices in toxicological analyses has been on the rise in clinical and forensic settings. Oral fluid (OF), as non-invasive fluid, has attracted attention in the field of drug screening, both for therapeutic and forensic purposes, as well as for medical diagnosis, clinical management, on-site (real time) doping and for monitoring environmental exposure to toxic substances. A good correlation between OF and blood is now established for drug concentrations. Therefore, OF might be a potential substitute of blood, especially for long-term surveillance (e.g., therapeutic drugs) or to screen a large number of patients, as well as for the development of salivary point-of-care technologies. In this review, we aimed to summarize and critically evaluate the current literature that focused on the comparison of drugs detection in OF and blood specimens. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14346621
- Volume :
- 61
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Clinical Chemistry & Laboratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 172415966
- Full Text :
- https://doi.org/10.1515/cclm-2023-0343