PLACK syndrome caused by novel pathogenic variants in CAST: a case report and literature review.

Herein we report on a patient with PLACK syndrome carrying compound heterozygous variants in I CAST i and provide a literature review. Dear Editor, PLACK syndrome (OMIM #616295) refers to an extremely rare autosomal-recessive genodermatosis characterized by a constellation of peeling skin, leuconychia, acral punctate keratoses, cheilitis and knuckle pads. [Extracted from the article]