CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation.

The article focuses on the role of Chitinase-3-like protein 1 (CHI3L1) in neuroinflammation and cognitive impairment, particularly in the context of neuroinflammatory disorders like neuromyelitis optica (NMO). It highlights how CHI3L1 is induced in astrocytes by proinflammatory stimuli and plays a detrimental role in neurogenesis, providing insights into potential therapeutic targets for neuroinflammatory disorders.