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Building smart CAR TÂ cell therapies: The path to overcome current challenges.
- Source :
-
Cancer Cell . Oct2023, Vol. 41 Issue 10, p1689-1695. 7p. - Publication Year :
- 2023
-
Abstract
- Successful implementation of adoptive cell therapy (ACT) of cancer requires comprehensively addressing biological and practical challenges. This approach has been largely overlooked, resulting in a gap between the potential of ACT and its actual effectiveness. We summarize the most promising technical strategies in creating an "ideal" ACT product, focusing on chimeric antigen receptor (CAR)-engineered cells. Since many requirements for effective ACT are common to most cancers, what we outline here might have a broader impact. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15356108
- Volume :
- 41
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Cancer Cell
- Publication Type :
- Academic Journal
- Accession number :
- 172778603
- Full Text :
- https://doi.org/10.1016/j.ccell.2023.08.011