Importancia de la integración clínica, hallazgos morfológicos e inmunofenotipo por citometría de flujo en el diagnóstico de leucemia de células peludas: informe de tres casos.

BACKGROUND: Hairy cell leukemia is a lymphoproliferative neoplasm of mature B cells, which can infiltrate the bone marrow or spleen. It represents 2% of lymphoid leukemias and initial clinical laboratory results range from cytopenias to pancytopenia. Morphological analysis and typical pattern of bone marrow infiltration and immuno- phenotypic profile includes expression of CD11c, CD103, and CD25. CLINICAL CASE: Three cases of patients diagnosed with hairy cell leukemia, with associated infections and long evolution of the disease, who were prescribed cladribine and rituximab, with satisfactory reaction, are presented. The complete diagnosis included: clinical, morpho-pathological, immuno-phenotypic and molecular analyses. CONCLUSIONS: The identification of risk factors and the design of the medical study depend on the notification and surveillance of patients with hairy cell leukemia, in addition to the inclusion of molecular tests that allow specific monitoring and the obtaining of prognostic data and therapeutic targets for the BRAF mutation. [ABSTRACT FROM AUTHOR]