Back to Search
Start Over
Periosteal Fasciitis With Unusual Radiologic Features Harboring a Novel STAG1::USP6 Fusion Gene.
- Source :
-
International Journal of Surgical Pathology . Oct2023, Vol. 31 Issue 7, p1387-1392. 6p. - Publication Year :
- 2023
-
Abstract
- Periosteal fasciitis is a subtype of nodular fasciitis originating from the periosteum. The diagnosis can be challenging and requires radiologic–pathologic correlation. Advances in molecular analysis confirmed that nodular fasciitis and its related lesions harbor a USP6 gene rearrangement with one of the several potential partners. Herein, we report a case of periosteal fasciitis with metaplastic bone formation detected incidentally during a radiologic survey for breast carcinoma. Radiologic examination revealed a 2.4 cm, heterogeneous, avidly enhancing lesion of the right femoral distal metaphysis concerning for low-grade periosteal chondrosarcoma. Histological examination of a core needle biopsy revealed a tumor composed of bland spindle cells with myofibroblastic and osteoblastic phenotypes admixed with immature bone and cartilaginous elements. Molecular analysis revealed a novel STAG1::USP6 fusion that helped arrive at the right diagnosis and further expands the molecular profile of USP6 -associated neoplasms. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BREAST
*GENE fusion
*FASCIITIS
*CORE needle biopsy
*GENE rearrangement
*BONE growth
Subjects
Details
- Language :
- English
- ISSN :
- 10668969
- Volume :
- 31
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- International Journal of Surgical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 172849023
- Full Text :
- https://doi.org/10.1177/10668969221150369