Application of chemometric modeling for ionic liquid-based ultrasonic-assisted dispersive liquid-liquid microextraction: Analysis of fosetyl-aluminum in fruit and vegetable samples.

This manuscript presents a new method for selective extraction and determination of fosetyl-aluminum in fruits and vegetable samples based on ultrasonic-assisted dispersive liquid-liquid microextraction method using ionic liquids (IL-UA-DLLME). A UV-Visible spectrophotometer was used for detection and quantification. Plants used for sample collection were grown under controlled conditions in a greenhouse. Central composite design (CCD)-response surface methodology (RSM) analysis was used for the optimization of significant factors (volume of IL, pH, ultrasonication time, and THF volume). Under optimal conditions, the limit of detection and limit of quantification of the IL-UA-DLLME procedure were 1.5 ng mL−1 and 5.0 ng mL−1 respectively with relative standard deviation 1.9–3.3%. The developed IL-UA-DLLME procedure demonstrated linearity within the concentration range of 5–600 ng mL−1 with an R2 value of 0.9914. The enrichment factor was 114 with a recovery% of 94.2–98.6% (n = 3) at optimal conditions. The IL-UA-DLLME assay was used for the analysis of fosetyl-aluminum in a variety of food samples and was found highly selective and efficient. [Display omitted] • Ionic liquid-based pre-concentration method for fosetyl-aluminum analysis in foods. • Increased mass transfer via DLLME for fungicide isolation from plant material. • Fully validated method with proved applicability to real samples and routine analysis. • A highly sensitive, selective, and robust assay for environmental monitoring. • Fast analyte isolation followed by spectroscopic final determination stage [ABSTRACT FROM AUTHOR]