Gold-Catalyzed Cyclization of Alkynyl Heteroarenes with a Norbornene Bridge.

Keywords: heterocycles; alkynes; cyclization; gold catalysis; norbornene EN heterocycles alkynes cyclization gold catalysis norbornene 3652 3661 10 10/19/23 20231102 NES 231102 Graph Direct C-H functionalization of heteroarenes has advanced significantly in recent decades, allowing access to a wide range of heteroarenes for the development of new pharmaceuticals and functional materials. Purification by flash column chromatography (silica gel, hexanes/EtOAc 200:1) provided B 1c b ; yield: 226 mg (63%); yellow solid; mp 110-112 °C. Purification by flash column chromatography (silica gel, hexanes/EtOAc 200:1) provided B 1e b ; yield: 451 mg (70%); orange liquid. Purification by flash column chromatography (silica gel, hexanes/EtOAc 100:1) provided B 1o b ; yield: 241 mg (95%); yellow liquid. [Extracted from the article]