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Gold-Catalyzed Cyclization of Alkynyl Heteroarenes with a Norbornene Bridge.
- Source :
-
Synthesis . Nov2023, Vol. 55 Issue 21, p3652-3661. 10p. - Publication Year :
- 2023
-
Abstract
- Keywords: heterocycles; alkynes; cyclization; gold catalysis; norbornene EN heterocycles alkynes cyclization gold catalysis norbornene 3652 3661 10 10/19/23 20231102 NES 231102 Graph Direct C-H functionalization of heteroarenes has advanced significantly in recent decades, allowing access to a wide range of heteroarenes for the development of new pharmaceuticals and functional materials. Purification by flash column chromatography (silica gel, hexanes/EtOAc 200:1) provided B 1c b ; yield: 226 mg (63%); yellow solid; mp 110-112 °C. Purification by flash column chromatography (silica gel, hexanes/EtOAc 200:1) provided B 1e b ; yield: 451 mg (70%); orange liquid. Purification by flash column chromatography (silica gel, hexanes/EtOAc 100:1) provided B 1o b ; yield: 241 mg (95%); yellow liquid. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 55
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 173036968
- Full Text :
- https://doi.org/10.1055/a-2039-5521