Back to Search Start Over

Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife.

Authors :
Dounavi, Maria-Eleni
Mak, Elijah
Swann, Peter
Low, Audrey
Muniz-Terrera, Graciela
McKeever, Anna
Pope, Marianna
Williams, Guy B
Wells, Katie
Lawlor, Brian
Naci, Lorina
Malhotra, Paresh
Mackay, Clare
Koychev, Ivan
Ritchie, Karen
Su, Li
Ritchie, Craig W
O'Brien, John T
Source :
Journal of Cerebral Blood Flow & Metabolism. Oct2023, Vol. 43 Issue 10, p1672-1684. 13p.
Publication Year :
2023

Abstract

Cerebral hemodynamic alterations have been observed in apolipoprotein ε4 (APOE4) carriers at midlife, however the physiological underpinnings of this observation are poorly understood. Our goal was to investigate cerebral blood flow (CBF) and its spatial coefficient of variation (CoV) in relation to APOE4 and a measure of erythrocyte anisocytosis (red blood cell distribution width – RDW) in a middle-aged cohort. Data from 563 participants in the PREVENT-Dementia study scanned with 3 T MRI cross-sectionally were analysed. Voxel-wise and region-of-interest analyses within nine vascular regions were run to detect areas of altered perfusion. Within the vascular regions, interaction terms between APOE4 and RDW in predicting CBF were examined. Areas of hyperperfusion in APOE4 carriers were detected mainly in frontotemporal regions. The APOE4 allele differentially moderated the association between RDW and CBF, an association which was more prominent in the distal vascular territories (p – [0.01, 0.05]). The CoV was not different between the considered groups. We provide novel evidence that in midlife, RDW and CBF are differentially associated in APOE4 carriers and non-carriers. This association is consistent with a differential hemodynamic response to hematological alterations in APOE4 carriers. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0271678X
Volume :
43
Issue :
10
Database :
Academic Search Index
Journal :
Journal of Cerebral Blood Flow & Metabolism
Publication Type :
Academic Journal
Accession number :
173037005
Full Text :
https://doi.org/10.1177/0271678X231173587