超声心动图参数联合血清 NT-pro BNP、suPAR、PTX-3 预测 慢性心力衰竭患者预后的临床研究.

Objective: To explore the clinical value of echocardiography parameters combine with serum N-terminal B-type brain natriuretic peptide (NT-pro BNP), soluble urokinase type plasminogen activator receptor (suPAR), and pentraxin-3 (PTX-3) in predicting the prognosis of patients with chronic heart failure (CHF). Methods: 122 patients with CHF who were admitted to the 909th Hospital of the Joint Logistics Support Force from January 2019 to October 2021 were selected as the CHF group, while 50 healthy individuals were selected as the control group during the same period. The echocardiographic parameters and serum NT-pro BNP, suPAR, and PTX-3 levels were compared between the two groups. Patients with CHF were followed up for 12 months after discharge, and they were divided into poor prognosis group and good prognosis group based on the prognosis, and the echocardiographic parameters and serum NT-pro BNP, suPAR, and PTX-3 levels were compared between the two groups. The predictive value of receiver operating characteristic (ROC) curve analysis of echocardiography parameters combined with serum NT pro BNP, suPAR, and PTX-3 for poor prognosis of patients with CHF. Results: Compared with the control group, left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), NT-pro BNP, suPAR, and PTX-3 of the CHF group were significantly increased (P<0.05), while left ventricular ejection fraction (LVEF) was significantly decreased (P<0.05). 122 patients with CHF were followed up for 12 months after discharge, including 35 patients with poor prognosis and 83 patients with good prognosis. Compared with the good prognosis group, LVEDD, LVESD, NT-pro BNP, suPAR, and PTX-3 of the poor prognosis group significantly increased (P<0.05), while LVEF significantly decreased (P<0.05). ROC curve analysis results showed that LVEDD, LVESD, and LVEF combined with NT-pro BNP, suPAR, and PTX-3 had the highest efficacy in predicting poor prognosis of CHF, significantly superior to the individual predictin of various indicators. Conclusion: Echocardiographic parameters LVEDD, LVESD, and LVEF combine with serum NT-pro BNP, suPAR, and PTX-3 have a high value in predicting poor prognosis of patients with CHF, which can serve as an auxiliary indicator for predicting the prognosis of patients with CHF. [ABSTRACT FROM AUTHOR]