体表心电图 QRS-T 夹角联合血清 NT-proBNP、Melatonin、galectin-3 预测 射血分数保留心力衰竭患者预后的临床研究.

Objective: To investigate the relationship between body surface ECG qrs-t angle and serum levels of N-terminal pro-B-type natriuretic peptide (NT proBNP), melatonin, and galectin-3 in predicting outcomes in patients with heart failure with preserved ejection fraction (HFPEF). Methods: 156 cases of patients with HFpEF who were admitted to the Wuhan Third Hospital from January 2020 to January 2022 were selected. Surface electrocardiogram examinations were performed on admission day, QRS-T Angle was recorded, serum NT-proBNP, Melatonin and galectin-3 levels were detected, and follow-up was conducted after discharge until June 2022. They were divided into poor prognosis group and good prognosis group according to the occurrence of adverse cardiovascular events. Multiple Logistic regression was used to analyze the prognostic factors of patients with HFpEF, and receiver operating characteristic curve (ROC) was used to analyze the value of QRS-T Angle combined with serum NT-proBNP, galectin-3 in predicting the prognosis of patients with HFpEF. Results: The QRS-T Angle in the poor prognosis group was larger than that in the good prognosis group, the serum NT-proBNP and galectin-3 levels were higher than those in the good prognosis group, and serum Melatonin level was lower than that in the good prognosis group (P＜0.05). Enlarged QRS-T Angle, elevated NT-proBNP, galectin-3 were risk factors for poor prognosis in patients with HFpEF (P＜0.05), and elevated Melatonin was a protective factor (P＜0.05). The area under curve of combining the four indicators to predict poor prognosis of patients with HFpEF was 0.899, which was higher than that predicted by alone. Conclusion: Enlarged QRS-T Angle, elevated serum NT-proBNP and galectin-3 levels, and decreased serum Melatonin level are associated with poor prognosis of HFpEF, and the combination of four indicators can help predict prognosis of HFpEF. [ABSTRACT FROM AUTHOR]