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SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion.
- Source :
-
Angiology . Nov2023, Vol. 74 Issue 10, p987-996. 10p. - Publication Year :
- 2023
-
Abstract
- SARS-Cov-2 has been suggested to promote thrombotic complications and higher mortality. The aim of the present study was to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) enrolled in the International Survey on Acute Coronary Syndromes ST-segment elevation Myocardial Infarction (ISACS-STEMI COVID-19 registry. The 109 SARS-CoV-2 positive patients were compared with 2005 SARS-CoV-2 negative patients. Positive patients were older (P =.002), less often active smokers (P =.002), and hypercholesterolemic (P =.006), they presented more often later than 12 h (P =.037), more often to the hub and were more often in cardiogenic shock (P =.02), or requiring rescue percutaneous coronary intervention after failed thrombolysis (P <.0001). Lower postprocedural Thrombolysis in Myocardial Infarction 3 flow (P =.029) and more thrombectomy (P =.046) were observed. SARS-CoV-2 was associated with a significantly higher in-hospital mortality (25.7 vs 7%, adjusted Odds Ratio (OR) [95% Confidence Interval] = 3.2 [1.71-5.99], P <.001) in-hospital definite in-stent thrombosis (6.4 vs 1.1%, adjusted Odds Ratio [95% CI] = 6.26 [2.41-16.25], P <.001) and 30-day mortality (34.4 vs 8.5%, adjusted Hazard Ratio [95% CI] = 2.16 [1.45-3.23], P <.001), confirming that SARS-CoV-2 positivity is associated with impaired reperfusion, with negative prognostic consequences. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THROMBOSIS complications
*COVID-19
*PERCUTANEOUS coronary intervention
*CONFIDENCE intervals
*SURGICAL stents
*ACUTE coronary syndrome
*HYPERCHOLESTEREMIA
*ST elevation myocardial infarction
*TREATMENT effectiveness
*HOSPITAL mortality
*COMPARATIVE studies
*HOSPITAL care
*CARDIOGENIC shock
*REPERFUSION
*ODDS ratio
*SMOKING
*EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 74
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 173048141
- Full Text :
- https://doi.org/10.1177/00033197221129351