Design, synthesis and biological evaluation of triazole, sulfonamide and sulfonyl urea derivatives of N-acylhomoserine lactone as quorum sensing inhibitors.

• A novel series of triazole, sulfonamide and sulfonyl urea derivatives of N -acylhomoserine lactones (HSL) have been prepared. • These novel molecules were screened against Chromobacterium violaceum ATCC 12472 for their quorum sensing inhibitory (QSI) activity. • Among them, compounds 6, 7 and 14 showed comparable antibacterial activities with reference to penicillin and streptomycin as 37.5 µg/mL, while compounds 7, 13 and 17 exhibited promising QSI activity. Triazole, sulfonamide and sulfonyl urea derivatives of N -acylhomoserine lactones (AHLs) have been prepared from homoserine lactone hydrobromide which in turn is derived from l -methionine. The molecules were screened against Chromobacterium violaceum ATCC 12472 for their quorum sensing inhibitory (QSI) activity. Among them, compounds 6, 7 and 14 were exhibited comparable antibacterial activities with reference to penicillin and streptomycin as 37.5 µg/mL, while compounds 7, 13 and 17 exhibited promising QSI activity. These compounds represent a synthetically accessible class of AHL analogs could find utility to improve their potency. [Display omitted] [ABSTRACT FROM AUTHOR]