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Use of Tunable Ligands Allows for Intermolecular Pd-Catalyzed C -- O Bond Formation.
- Source :
-
Journal of the American Chemical Society . 6/8/2005, Vol. 127 Issue 22, p8146-8149. 4p. - Publication Year :
- 2005
-
Abstract
- Bulky biaryl phosphine ligands facilitate Pd-catalyzed C--O coupling reactions of aryl halides with primary and secondary alcohols by promoting reductive elimination at the expense of β-hydride elimination. The key to their success is the ability to match the size of the ligand to that of the combination of substrates. The efficient coupling of a number of unactivated aryl chlorides and bromides with cyclic and acyclic secondary alcohols was achieved. This included the coupling of allylic alcohols for the first time in a Pd-catalyzed coupling process. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 127
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 17320231
- Full Text :
- https://doi.org/10.1021/ja050471r