空腹血糖水平对乙型肝炎病毒相关慢加急性 肝衰竭患者疾病转归的影响.

Objective To explore the effect of fasting blood glucose（FPG） on the prognosis of disease in patients with HBV-related acute-on-chronic liver failure. Methods The clinical data of 109 HBV-related ACLF patients admitted to the Department of Infectious Diseases of a tertiary a hospital in Yunnan Province were retrospectively analyzed, and grouped according to different FPG levels and prothrombin international standardized ratio（PT-INR） of prothrombin. ANOVA test, Chi-square test, Spearman correlation analysis and binary logistic regression were used to analyze the effect of FPG level on the prognosis of disease of HBV-related ACLF patients. Results The incidence and mortality of HBV-related ACLF complications （HE, hyponatremia, SBP） in low FPG group were higher than those in normal FPG and high FPG group （P < 0.05）. The incidence of low FPG and mortality of patients in middle-late stage group were higher than those in pre-early stage group （P < 0.05）. Child-Pugh score, MELD score and INR were positively correlated （P < 0.001）. Binary Logistic regression analysis showed that low FPG and normal FPG were independent risk factors for disease progression in HBV-related ACLF patients （OR = 0.174, 95%CI: 0.066 ~ 0.461, P < 0.05）. Conclusion Low FPG increases the risk of worsening disease progression in patients with HBV-related ACLF, while high FPG may play a role in protecting liver function. [ABSTRACT FROM AUTHOR]