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Berberine-induced glucagon-like peptide-1 and its mechanism for controlling type 2 diabetes mellitus: a comprehensive pathway review.
- Source :
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Archives of Physiology & Biochemistry . Nov2023, p1-8. 8p. 4 Illustrations, 1 Chart. - Publication Year :
- 2023
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Abstract
- Abstract <bold>Introduction:</bold> A growing number of studies have thus far showed the association between type 2 diabetes mellitus (DM) and the intestinal microbiome homoeostasis. As reported, the gut microflora can be significantly different in patients with type 2 DM (T2DM) compared to those in healthy individuals. <bold>Methods:</bold> The authors collected the relevant articles published until 2022 and these are carefully selected from three scientific databases based on keywords. <bold>Discussion:</bold> This review highlights research on the anti-diabetic properties of berberine (BBR)-induced glucagon-like peptide-1 (GLP-1), as a glucose-lowering factor and a balance regulator in the microbial flora of the intestines, which plays an important role in adjusting the signalling pathways affecting insulin secretion. <bold>Results:</bold> Considering the anti-diabetic characteristics of the BBR-induced GLP-1, BBR makes a promising complementary treatment for reducing the clinical symptoms of DM by reducing the hyperglycaemia. Berberin might be a safe and effective drug for T2DM with little or no adverse effects. Highlights Berberine induces GLP-1 insulin secretion by PLC2 pathway in the intestinal Berberine-induced GLP-1 decreases mitochondrial stress and relocates cytochrome c out of the mitochondria. Berberine induces GLP-1 secretion in the intestine by altering the bacterial profile, thus could possibly lighten diabetes symptoms Berberine-induced SCFA production, SCFA causes GLP-1 secretion from the intestinal L-Cell. Preventing mitochondrial damage, reducing adipose tissue fat, and reducing oxidative stress are thus among the results of BBR-induced GLP-1. The lower costs of BBR, and its limited side effects and higher availability, make it a promising supplementary medicine for DM Berberine induces GLP-1 insulin secretion by PLC2 pathway in the intestinalBerberine-induced GLP-1 decreases mitochondrial stress and relocates cytochrome c out of the mitochondria.Berberine induces GLP-1 secretion in the intestine by altering the bacterial profile, thus could possibly lighten diabetes symptomsBerberine-induced SCFA production, SCFA causes GLP-1 secretion from the intestinal L-Cell.Preventing mitochondrial damage, reducing adipose tissue fat, and reducing oxidative stress are thus among the results of BBR-induced GLP-1.The lower costs of BBR, and its limited side effects and higher availability, make it a promising supplementary medicine for DM [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13813455
- Database :
- Academic Search Index
- Journal :
- Archives of Physiology & Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 173391285
- Full Text :
- https://doi.org/10.1080/13813455.2023.2258559