Human Toll-like receptor 2 genetic polymorphisms with tuberculosis susceptibility: A systematic review and meta-analysis.

• The relationship between TLR2 polymorphism and TB susceptibility is not as close as we thought before. • Screening more gene mutations to provide new ideas for prevention and treatment of TB. • TLR2 rs5743708 polymorphism exhibits a significant association with a higher tuberculosis risk. • The polymorphism of TLR2 gene was systematically reviewed for the first time. Toll-like receptor 2 (TLR2) is a crucial factor in the development of tuberculosis. However, no studies have explored the association between TLR2 polymorphisms and tuberculosis susceptibility. This study aimed to explore the correlation between tuberculosis susceptibility and TLR2 polymorphisms (rs3804099, rs3804100, rs1898830, rs5743708, rs121917864, and (-196-174) del). All relevant online databases including PubMed, CNKI, WANFANG DATA, and METSTR-FMRS were systematically searched. STATA17.0 (Stata Corp LP, College Station, Texas, USA) was used. A total of 37 studies, covering six polymorphisms and comprising 9,474 cases and 10,295 controls, were included in this analysis. rs3804099(C vs T: OR = 1.00, 95 % CI: 0.93–1.08, CC + TC vs TT: OR = 1.04, 95 % CI: 0.98–1.10), rs3804100 (C vs T: OR = 1.19, 95 % CI: 0.93–1.07, CC + TC vs TT: OR = 0.97, 95 % CI: 0.89–1.06), rs1898830(G vs A: OR = 0.90, 95 % CI: 0.81–1.00, GG + AG vs AA: OR = 0.87, 95 % CI: 0.67–1.12), (-196 ∼174) del polymorphism (Del vs Ins: OR = 0.93,95 % CI: 0.76–1.14, DD + DI vs II: OR = 0.92,95 % CI: 0.72–1.17). This study indicated that only the TLR2 rs5743708 polymorphism exhibited a significant association with a higher tuberculosis risk, while TLR2 rs3804099, rs3804100, rs1898830, rs121917864, and (-196-174) del polymorphisms were not associated with tuberculosis susceptibility. [ABSTRACT FROM AUTHOR]