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Real-time semantic segmentation and anomaly detection of functional images for cell therapy manufacturing.

Authors :
Chen, Rui Qi
Joffe, Benjamin
Casteleiro Costa, Paloma
Filan, Caroline
Wang, Bryan
Balakirsky, Stephen
Robles, Francisco
Roy, Krishnendu
Li, Jing
Source :
Cytotherapy (Elsevier Inc.). Dec2023, Vol. 25 Issue 12, p1361-1369. 9p.
Publication Year :
2023

Abstract

Cell therapy is a promising treatment method that uses living cells to address a variety of diseases and conditions, including cardiovascular diseases, neurologic disorders and certain cancers. As interest in cell therapy grows, there is a need to shift to a more efficient, scalable and automated manufacturing process that can produce high-quality products at a lower cost. One way to achieve this is using non-invasive imaging and real-time image analysis techniques to monitor and control the manufacturing process. This work presents a machine learning-based image analysis pipeline that includes semantic segmentation and anomaly detection capabilities. This method can be easily implemented even when given a limited dataset of annotated images, is able to segment cells and debris and can identify anomalies such as contamination or hardware failure. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14653249
Volume :
25
Issue :
12
Database :
Academic Search Index
Journal :
Cytotherapy (Elsevier Inc.)
Publication Type :
Academic Journal
Accession number :
173524255
Full Text :
https://doi.org/10.1016/j.jcyt.2023.08.011