ANTIMALARIAL ACTIVITY OF NEWLY SYNTHESIZED N-(8-HYDROXY QUINOLIN-5-YL)-2,4,6-TRIMETHYL BENZENESULFONAMIDE (8HQTBS) LIGAND AND THEIR METAL CHELATES.

The ligand namely N-(8-hydroxyquinolin-5-yl)-2,4,6-trimethylbenzene sulfonamide (8HQTBS) and its complexes with transition metals were synthesized using transition metal ions. Prepared ligand and their metal complexes were examined by the study of physicochemical properties, various spectral techniques, and magnetic susceptibility. Octahedral geometry of the transition metal complexes was proposed by spectral studies. The antimicrobial profile of prepared ligands and complexes (In vitro) showed better activity of ligands after metal complexation. Strong binding of transition metal complexes with CT-DNA was observed through the intercalation mechanism. A comparative molecular docking study between bacterial proteins and a DNA helix was performed, and the docking results obtained were in good agreement with the spectroscopic results. Some of the compounds showed good to moderate antimalarial activity. [ABSTRACT FROM AUTHOR]