ALUM CATALYZED AN ECO-FRIENDLY SYNTHESIS OF BENZYLIDENE MALONONITRILE AND BENZYLIDENE BARBITURIC ACID DERIVATIVES IN AQUEOUS MEDIUM.

Alum-catalyzed Knoevenagel reaction of substituted aromatic aldehydes and active methylene compounds such as malononitrile and barbituric acid using green, eco-friendly solvent, water was developed. The protocol is practically simple and found efficient. The condensation is carried out in a short reaction time and the desired products are obtained in excellent yields. Furthermore, The catalyst utilized is readily accessible, cost-effective, environmentally friendly, and safe. The derivatives are among the most frequently used intermediate in heterocyclic synthesis. The synthesized benzylidene derivatives were characterized by spectral analysis. [ABSTRACT FROM AUTHOR]