Apigenin'in Potansiyel Farmakolojik Etkileri Üzerine Bir Derleme.

Apigenin is one of the flavonoids found in abundance in various natural sources, including fruits and vegetables, with important functions in the prevention and treatment of various health problems. It is known that apigenin, which has a very high pharmacological activity, has mainly antioxidant, anti-inflammatory and anti-neoplastic effects, and exhibits these effects by up-or down-regulating proteins in specific pathways. This study focused on the effects of apigenin on inflammation, oxidant-antioxidant balance, cancer, apoptosis and cell cycle, and these properties were supported by in vivo and in vitro studies. As a result of the researches, it was concluded that apigenin exhibits anti-inflammatory, antioxidant and anti-carcinogenic properties. Moreover, it has been observed that apigenin leads damaged, worn or cancerous cells to apoptosis, inhibits the proliferation of such cells by stopping the cell cycle at various checkpoints, and thus exhibits an antiproliferative effect. [ABSTRACT FROM AUTHOR]