Computational approach in cardiac arrhythmias to analyse sodium (Na+) concentration of extracellular and intracellular fluid effects in purkinje fibre cell for action potential depolarization phase generation using Euler integration method. A simulation study

The aim of this study is to analyze synchronisation and coordination of purkinje fibre cells (PFC) with ventricular myocardium. In that particular focus on Sodium (Na+) concentration is responsible for Action potential (AP) generation. Here this paper is based on the model of Humanendocardial cell by Aslandi (ALD). The ALD model data is modified based on the experimental data of Han, describing the properties of Na+ currents in human PFC. Euler integration protocol is used to analyze the human PFC model for different concentration failure conditions in the same group of 100 samples by keeping threshold 0.05, G power 80%, confidence interval 95% and enrolment ratio 1. The normal AP is -53.04 mV for normal Extracellular Na+ Concentration (Na+o =140mM) and for different increasing levels of Na+o in PFC like (10%=154mM, 25%=175mM, 50%=210mM, 100%=280mM) having AP as (10%= -52.56mV, 25%= -56.26mV, 50%= -44.56mV, 100%= -39.39mV). AP for different decreasing levels of Na+o in PFC like (10%= 126mM, 25%=105mM, 50%=70mM, 100%=0.1mM) having (10%= -51.98mV, 25%= -72.02mV, 50%= -75.75mV, 100%= -75.35mV). AP for different increasing level of intracellular Na+ concentration (Na+i)in PFC like (10%=8.8mM, 25%=10mM, 50%=12mM, 100%=16mM) having AP (10%=-53.08mV, 25%=-70.58mV, 50%=-73.47mV, 100%=-76.76mV), AP for different decreasing levels of Na+i in PFC like (10%=7.2mM, 25%=6mM, 50%=4mM, 100%=0.1mM) having (10%=-46.46mV, 25%=34.92mV, 50%=-28.98mV, 100%= -25.14mV). Similarly its mean value of fast Na current (INa in Pico Ampere (pA)) varied according to different deviant conditions. The results of normal and abnormal concentration of Na+ in intracellular and extracellular PFC affects the depolarization phase due to prolonged total cycle length of AP which leads to cardiac failure. [ABSTRACT FROM AUTHOR]