Generalized lichen sclerosus responding to UVA1 phototherapy and methotrexate treatment: A case report.

This article discusses a case report of a 70-year-old woman with generalized lichen sclerosus (LS) who experienced complete improvement with UVA1 phototherapy and methotrexate treatment. LS is an inflammatory disease characterized by porcelain-white atrophic plaques, primarily in the anogenital region but can also occur in extragenital areas. The patient had underlying diseases and the LS lesions were resistant to topical treatments. After UVA1 phototherapy and subsequent methotrexate treatment, the patient experienced regression of lesions and symptoms. LS can be treated with various methods, including topical corticosteroids, phototherapy, and systemic medications like methotrexate. The combination of UVA1 phototherapy and methotrexate may be an alternative therapy for patients with treatment-resistant widespread LS lesions. [Extracted from the article]