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A fluorescent prodrug to fight drug-resistant lung cancer cells via autophagy-driven ferroptosis.
- Source :
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Sensors & Actuators B: Chemical . Feb2024:Part B, Vol. 400, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
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Abstract
- Lung cancer is the second most common malignant tumor worldwide. The problem of drug resistance in lung cancer leads to treatment failure and recurrence in more than 90% of cancer patients. Thus, developing chemical probes that can observe drug-resistant lung cancer cells in real-time and eliminate them is of great interest. However, such tools that can simultaneously probe drug-resistant lung cancer cells and therapeutic modes of action have not yet been developed. In this work, we reported a fluorescent prodrug that can be activated in cancer cell lysosomes to release amonafide (ANF) and aniline mustard, where the fluorescent signal of ANF (λ ex /λ em = 405/570 −620 nm) can be tracked by super-resolution imaging in live cancer cells. With imaging studies, we found that this new fluorescent prodrug uniquely displays an autophagy-driven ferroptosis-inducing effect, accompanied by the accumulation of intracellular ferrous ions and lipid peroxidation. More importantly, the fluorescent prodrug exhibits potential anti-proliferative activity, especially against drug-resistant A549R lung cancer cells (IC 50 , ∼ 3 μM), better than the positive control drug cisplatin (IC 50 , ∼ 27 μM). This work indicates that the development of fluorescent prodrugs as autophagy-driven ferroptosis inducers may represent a viable approach for targeting drug-resistant cancer cells. [Display omitted] • A new fluorescent prodrug for fighting drug-resistant lung cancer cells was developed. • This fluorescent prodrug can be activated in cancer cell lysosomes to release ANF. • The fluorescent signal of ANF can be tracked by super-resolution imaging in live cells. • This new fluorescent prodrug displays an autophagy-driven ferroptosis-inducing effect. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09254005
- Volume :
- 400
- Database :
- Academic Search Index
- Journal :
- Sensors & Actuators B: Chemical
- Publication Type :
- Academic Journal
- Accession number :
- 173697998
- Full Text :
- https://doi.org/10.1016/j.snb.2023.134871