蓝刺头黄酮对小鼠 血清免疫指标和抗氧化指标的影响.

The experiment was to study the effect of Echinops latifolius Tausch flavonoids on immune and antioxidant indexes of mice. A total of 80 Kunming mice were randomly divided into four groups, with 20 replicates in each group and one mouse in each replicate. The mice in low dose group, middle dose group, and high dose group were gavaged with 100, 200 and 400 mg/kg Echinops latifolius Tausch flavonoids, respectively, and the mice in the blank control group were treated with the same amount of distilled water. The experiment lasted for 30 d. The results showed that compared with control group, the thymus and spleen indexes of the mice in each dose group were increased (P>0.05), and the thymus index of high-dose group was significantly higher than that of control group (P<0.05). The serum levels of IgG and IgA in high-dose group were significantly higher than those in control group (P<0.05), and the serum level of IgM was slightly higher than that in control group (P>0.05). The serum IgA level in medium-dose group was significantly higher than that in control group (P<0.05). Compared with control group, the serum levels of IL-1β in high-dose group and medium-dose group were extremely decreased (P<0.01), and the serum levels of IL-6 and TNF-α in high-dose group were significantly decreased (P<0.05). The serum IL-6 of mice in medium dose group was significantly rdecreased (P<0.05). The activity of SOD in serum of mice in high, medium and low dose groups were significantly higher than those in control group (P<0.05), and GSH-Px activity was extremely higher than control group (P<0.01). The serum T-AOC of mice in high and low dose group was extremely higher than that in control group (P<0.01), and the serum MDA content of mice in high dose group was extremely lower than that in control group (P<0.01). The study indicates that the Echinops latifolius Tausch flavonoids can promote the development of immune organs in mice, enhance the antioxidant capacity of mice, and improve the immune function of mice, and adding 400 mg/kg flavonoid solution has the best effect. [ABSTRACT FROM AUTHOR]