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A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration.
- Source :
-
Scientific Reports . 11/20/2023, Vol. 13 Issue 1, p1-11. 11p. - Publication Year :
- 2023
-
Abstract
- The transport and accumulation of orally administered functional food-derived peptides in the brain was not fully explored. Thus, in the present study, we aimed to provide critical evidence regarding brain accumulation of a memory-improving soy dipeptide, Tyr-Pro, following oral administration. Stable isotope-labeled Tyr-Pro (Tyr-[13C5,15N]Pro) was orally administered to male ICR mice at 10 or 100 mg/kg. Surprisingly, the intact labeled Tyr-Pro exhibited maximal plasma and brain levels 15 min after administration (plasma: area under the curve [AUC0–120 min], 1331 ± 267 pmol·min/mL-plasma; brain: AUC0–120 min of 0.34 ± 0.11 pmol·min/mg-dry brain, at 10 mg/kg). In addition, we detected labeled Tyr-Pro in the brain parenchyma, indicating a validated blood–brain-barrier (BBB) transportability. Moreover, we confirmed the preferable accumulation of Tyr-Pro in the hypothalamus, hippocampus, and cortex with > 0.02 pmol/mg-tissue. In conclusion, we provided the first evidence that orally administered Tyr-Pro at 10 mg/kg directly entered the blood circulation with an absorption ratio of 0.15%, of which 2.5% of Tyr-Pro was transported from the plasma to the mouse brain parenchyma. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ORAL drug administration
*NEUROPEPTIDES
*LABORATORY mice
*MICE
*HIPPOCAMPUS (Brain)
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 13
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- 173764974
- Full Text :
- https://doi.org/10.1038/s41598-023-44161-z