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An Overview of SARS-CoV-2 Etiopathogenesis and Recent Developments in COVID-19 Vaccines.

Authors :
Mathew, Dona Susan
Pandya, Tirtha
Pandya, Het
Vaghela, Yuzen
Subbian, Selvakumar
Source :
Biomolecules (2218-273X). Nov2023, Vol. 13 Issue 11, p1565. 18p.
Publication Year :
2023

Abstract

The Coronavirus disease-2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has significantly impacted the health and socioeconomic status of humans worldwide. Pulmonary infection of SARS-CoV-2 results in exorbitant viral replication and associated onset of inflammatory cytokine storm and disease pathology in various internal organs. However, the etiopathogenesis of SARS-CoV-2 infection is not fully understood. Currently, there are no targeted therapies available to cure COVID-19, and most patients are treated empirically with anti-inflammatory and/or anti-viral drugs, based on the disease symptoms. Although several types of vaccines are currently implemented to control COVID-19 and prevent viral dissemination, the emergence of new variants of SARS-CoV-2 that can evade the vaccine-induced protective immunity poses challenges to current vaccination strategies and highlights the necessity to develop better and improved vaccines. In this review, we summarize the etiopathogenesis of SARS-CoV-2 and elaborately discuss various types of vaccines and vaccination strategies, focusing on those vaccines that are currently in use worldwide to combat COVID-19 or in various stages of clinical development to use in humans. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2218273X
Volume :
13
Issue :
11
Database :
Academic Search Index
Journal :
Biomolecules (2218-273X)
Publication Type :
Academic Journal
Accession number :
173832790
Full Text :
https://doi.org/10.3390/biom13111565