Circulating Tfr/Tfh cell imbalance may contribute to the immunopathogenesis of pemphigus.

This article explores the potential role of an imbalance between two types of immune cells, cTfr and cTfh cells, in the development of pemphigus, a skin disease. The study found that patients with pemphigus had higher levels of cTfh cells and lower levels of cTfr cells compared to healthy individuals. This imbalance was associated with the production of specific antibodies and the severity of the disease. The study suggests that targeting the cTfr/cTfh cell ratio could be a potential treatment approach for pemphigus. [Extracted from the article]