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Exploring the Antimicrobial Potential of Pyrimidine Linked Hydrazinyl Azole Derivatives: Insights from Biological Assays and Molecular Docking Studies.
- Source :
-
ChemistrySelect . 11/24/2023, Vol. 8 Issue 44, p1-13. 13p. - Publication Year :
- 2023
-
Abstract
- We present a study on a new class of Schiff bases with pyrimidine linked hydrazinyl azole backbone. These compounds were synthesized using conventional and ultrasonication methods. Our design strategy incorporated three heteroaromatic azoles and various substituents on the pyrimidine scaffold to enhance antimicrobial properties. Antibacterial and antifungal screenings were conducted against specific pathogens, and molecular docking studies supported the results. The compounds exhibited significant antimicrobial activities, particularly against K. pneumoniae, surpassing the standard drug. These Schiff bases hold promise as potential antimicrobial agents. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MOLECULAR docking
*BIOLOGICAL assay
*SCHIFF bases
*PYRIMIDINES
*AZOLES
*SONICATION
Subjects
Details
- Language :
- English
- ISSN :
- 23656549
- Volume :
- 8
- Issue :
- 44
- Database :
- Academic Search Index
- Journal :
- ChemistrySelect
- Publication Type :
- Academic Journal
- Accession number :
- 173925065
- Full Text :
- https://doi.org/10.1002/slct.202301998