Access to Fluorinated Quaternary Stereogenic Centers via Palladium-Catalyzed Asymmetric Allylic C–H Alkylation.

This document discusses the challenges and methods for constructing fluorinated quaternary stereogenic centers in organic molecules, which are important in pharmaceuticals. The authors present a Pd-catalyzed allylic C–H alkylation method using an α-fluoroester for the construction of a C–F quaternary stereogenic center. They found that using a chiral phosphoramidite-palladium catalyst and 2,5-diphenylhydroquinone as an oxidant resulted in high yields and selectivities. The researchers also explored the substrate scope and proposed a plausible reaction mechanism. Overall, this study provides an efficient method for synthesizing fluorinated quaternary stereogenic centers. [Extracted from the article]