Development of a biosensor based on a surface plasmon resonance structure comprising strontium titanate, graphene and affinity layers for malaria diagnosis.

This paper investigates the numerical analysis of a highly performed surface plasmon resonance (SPRE)-based sensor employing a hybrid structure of SrTiO3 (STO) and graphene for rapid detection of malaria. The investigation is performed using the angular interrogation technique and transfer matrix method. The SPRE device has a glass prism, silver (Ag), STO, graphene, affinity layer and sensing medium (SGM). Four coupling prisms are examined and we found the prism N-FK51A corresponds to the highest sensitivity. The sensitivity of the structure N-FK51A/Ag/STO/graphene/affinity layer/SGM is found to be 205.405, 222.222 and 2 5 8. 3 3 3 ∘ /RIU for Schizont, Trophozoite and Ring malaria stages. The layer thicknesses are then optimized and it is found that the proposed SPRE sensor can achieve a sensitivity of 278.378, 227.027 and 4 0 0 ∘ /RIU for Schizont, Trophozoite and Ring malaria stages with 30 nm (silver), 1 nm (STO), mono-sheet of graphene and 5 nm of the affinity layer. These findings demonstrate that the proposed method and structure can be used efficiently for biomedical applications. [ABSTRACT FROM AUTHOR]