Palladium-catalyzed cyclization/carbonylation of iodoarene-tethered propargyl ethers with nitroarenes for the synthesis of acetamides-functionalized benzofurans.

A general and efficient protocol based on palladium-catalyzed intramolecular cyclization and reductive aminocarbonylation of iodoarene-tethered propargyl ethers and nitroarenes for the synthesis of acetamide-functionalized benzofurans has been explored. [Display omitted] • A straightforward palladium-catalyzed cyclization/carbonylation reaction of iodoarene-tethered propargyl ethers for the synthesis of acetamides-functionalized benzofurans has been developed. • Nitroarenes has been applied as the nitrogen sources and Mo(CO) 6 played a dual role as both CO precursor and reductant. • A variety of acetamides-functionalized benzofurans were prepared in good yields with very good substrate tolerance. A general and efficient protocol based on palladium-catalyzed intramolecular cyclization and reductive aminocarbonylation reaction for the synthesis of acetamide-functionalized benzofurans has been explored. The reaction using iodoarene-tethered propargyl ethers and nitroarenes as the starting materials. This reaction features the formation of structure defined benzofurans with acetamides as attractive functional groups in a single step operation. By using Mo(CO) 6 as both CO source and reductant, a variety of acetamides-functionalized benzofurans were obtained in moderate to good yields with good functional group compatibility. [ABSTRACT FROM AUTHOR]