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Defluorinative 1,3‐Dienylation of Fluoroalkyl N‐Triftosylhydrazones with Homoallenols.
- Source :
-
Chemistry - A European Journal . Dec2023, Vol. 29 Issue 67, p1-7. 7p. - Publication Year :
- 2023
-
Abstract
- A silver‐catalyzed regioselective defluorinative 1,3‐dienylation of trifluoromethyl phenyl N‐triftosylhydrazones using homoallenols as 1,3‐dienyl sources provides a variety of α‐(di)fluoro‐β‐vinyl allyl ketones with excellent functional group tolerance in moderate to good yields. The reaction proceeds through a silver carbene‐initiated sequential etherification and Claisen type [3,3]‐sigmatropic rearrangement cascade. The synthetic utility of this protocol was demonstrated through the downstream synthetic elaboration toward diverse synthetically useful building blocks. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FUNCTIONAL groups
*KETONES
*SILVER
*ETHERIFICATION
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 29
- Issue :
- 67
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 173975187
- Full Text :
- https://doi.org/10.1002/chem.202302562