Colokinetic co‐operation to control colorectal motility.

The study published in the Journal of Physiology explores the role of ghrelin receptor (GHSR) in modulating dopamine and serotonin actions on preganglionic neurons (PGNs) in the lumbosacral defecation center of the spinal cord. Researchers found that GHSR interacts with dopamine D2 receptors to induce excitatory responses in PGNs, contrary to the typical inhibitory effects of D2 receptor activation. This interaction may have implications for regulating colorectal motility and could potentially lead to new pharmacotherapies for gastrointestinal and autonomic functions. The study sheds light on the complex interplay of GPCRs in the spinal cord and their impact on neural regulation of colorectal activity. [Extracted from the article]