Effect of the oxygenic groups on activated carbon on its hemocompatibility.

In this research, the effect of the oxygenic groups on activated carbon on its hemocompatibility was studied by liquid-phase oxidation to introduce oxygenic groups on its surface and subsequent heat treatment under a nitrogen environment to remove these groups. Hemocompatibility was assessed through coagulation, hemolysis, platelet adhesion, and protein adsorption using rabbit blood samples. Results showed that an increasing presence of oxygenic groups improved hemocompatibility, evidenced by enhanced coagulation, reduced hemolysis, better platelet adhesion, and decreased fetal bovine serum protein adsorption. Conversely, the removal of oxygenic groups diminished hemocompatibility, except for coagulation when groups were removed at 250 ℃ for 15 min. Therefore, this research presents a promising route to enhance the hemocompatibility of activated carbon, offering insights into surface modification for improved biomaterial design. • Present a promising route to enhance the hemocompatibility of activated carbon. • An increasing presence of oxygenic groups improves hemocompatibility. • Removal of oxygenic groups confirmed effect oxygenic groups. • The improved hemocompatibility was discussed. • Removal of oxygenic groups at 250 ℃ for 15 min reduces blood coagulation. [ABSTRACT FROM AUTHOR]