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CO2 Laser Therapy for Treating Lichen Sclerosus: A Prospective Case Series.
- Source :
-
Journal of Gynecologic Surgery . Dec2023, Vol. 39 Issue 6, p295-299. 5p. - Publication Year :
- 2023
-
Abstract
- Objective: The goal of this research was to determine the efficacy of fractionated carbon dioxide (CO2) laser therapy for reducing symptoms of vulvar lichen sclerosus (LS). Materials and Methods: This was a prospective case series. The study participants were 23 women with active vulvar LS, confirmed via biopsy, who were abstaining from topical and systemic treatments for at least 4 weeks before enrollment. Subjects received 3–5 treatments with the CO2 laser, based on symptom improvements. The primary endpoint was a reduction by >50%, as shown by a composite examination-based and symptom-based score at 6 months post-treatment. A secondary endpoint was changes in the Vulvar Quality of Life Questionnaire and patient-supplied Patient Global Impression of Improvement (PGI) scores. A t-test was used to contrast pre-treatment and post-treatment changes in symptoms Results: From 2015 to 2020, 23 women participated in the study. The primary endpoint of >50% reduction in the composite symptom score was not significant; p = 0.08, although a reduction was significant at that time point; p = < 0.01. At 12 months a >50% reduction was significant; p = 0.03. Secondary outcomes were remarkable for significant reductions in symptoms that did not meet the >50% threshold at 6 and at 12 months. Mean satisfaction was 2.47 ± 0.61 on a 3-point scale and significantly positive PGI scores through the post-treatment follow-up time point. Conclusions: Exploration of fractionated CO2 for treating vulvar LS should be continued. (J GYNECOL SURG 39:295) [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10424067
- Volume :
- 39
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Gynecologic Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 173989466
- Full Text :
- https://doi.org/10.1089/gyn.2023.0013