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Real-world clinical effectiveness on glycaemic parameters, safety and additional benefits of Glargine U300 (Toujeo®) initiation after oral antidiabetic drug failure in insulin-naïve patients with type 2 diabetes mellitus.
- Source :
-
Indian Journal of Endocrinology & Metabolism . Sep/Oct2023, Vol. 27 Issue 5, p426-430. 5p. - Publication Year :
- 2023
-
Abstract
- Background: Several studies have proved the advantages of second-generation insulin analogs in lowering intra-individual variability in plasma insulin levels, flexibility in dosing, a sustained glucose-lowering effect, and decreasing the risk of hypoglycemia. Glargine 300 is one of the newer second-generation basal insulin analogs to have been approved for both type 1 and 2 diabetes. The present study aims to assess the real-world clinical effectiveness and safety of Glargine U300 (Toujeo®) initiation after oral antidiabetic drug failure in insulin-naïve patients with T2DM. Methods: A prospective, observational study was conducted where participants were interviewed regarding their basic demographics, body weight, and treatment details. Glycemic parameters (HbA1C%, Fasting Plasma Glucose, and Post Prandial Blood Glucose) were observed in the initial 6 months, and changes were noted and compared. Any hypoglycemic events or other complications were also noted. Data collected were statistically analyzed. Results: The study included a total of 188 patients. Treatment with glargine 300 significantly reduced the mean HbA1C level from 9.78% at baseline to 7.90% at the end of 6 months of treatment (p < 0.001). 10.60% of patients achieved the glycemic target of ≤7.0% by the end of 6 months, while only 6.90% were within the target range at baseline. Similarly, significant reduction in FPG was observed at the end of 6 months treatment period with Glargine U300. A significant increase in dose requirement was observed throughout the study phase (p < 0.001). Incidence of hypoglycemia was noted in 2.12% of subjects. Conclusion: The lower incidence statistics of hypoglycemia coupled with sustained positive glycemic effects, stands out to be a prominent advantage of Glargine U300 over its other congeners. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22308210
- Volume :
- 27
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Indian Journal of Endocrinology & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 173997861
- Full Text :
- https://doi.org/10.4103/ijem.ijem_57_23