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Post-hospitalization rehabilitation alleviates long-term immune repertoire alteration in COVID-19 convalescent patients.
- Source :
-
Cell Proliferation . Oct2023, Vol. 56 Issue 10, p1-16. 16p. - Publication Year :
- 2023
-
Abstract
- The global pandemic of Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an once-in-a-lifetime public health crisis. Among hundreds of millions of people who have contracted with or are being infected with COVID-19, the question of whether COVID-19 infection may cause long-term health concern, even being completely recovered from the disease clinically, especially immune system damage, needs to be addressed. Here, we performed seven-chain adaptome immune repertoire analyses on convalescent COVID-19 patients who have been discharged from hospitals for at least 6 months. Surprisingly, we discovered lymphopenia, reduced number of unique CDR3s, and reduced diversity of the TCR/BCR immune repertoire in convalescent COVID-19 patients. In addition, the BCR repertoire appears to be activated, which is consistent with the protective antibody titres, but serological experiments reveal significantly lower IL-4 and IL-7 levels in convalescent patients compared to those in healthy controls. Finally, in comparison with convalescent patients who did not receive post-hospitalization rehabilitation, the convalescent patients who received post-hospitalization rehabilitation had attenuated immune repertoire abnormality, almost back to the level of healthy control, despite no detectable clinic demographic difference. Overall, we report the potential long-term immunological impairment for COVID-19 infection, and correction of this impairment via post-hospitalization rehabilitation may offer a new prospect for COVID-19 recovery strategy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09607722
- Volume :
- 56
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Cell Proliferation
- Publication Type :
- Academic Journal
- Accession number :
- 174042187
- Full Text :
- https://doi.org/10.1111/cpr.13450