维生素 D 在妊娠期肝内胆汁淤积症患者血清和 脐带血的水平及其与总胆汁酸的相关性研究.

Objective To evaluate the changes in vitamin D levels in patients with intrahepatic cholestasis of pregnancy (ICP) and to analyze the correlation between vitamin D and total bile acids (TBA) levels. Methods A total of 60 pregnant women were selected (30 in the normal group and 30 in the ICP group) . Demographic characteristics and perinatal data were recorded and collected. Serum TBA concentration, liver function, total cholesterol, triglyceride and serum 25 (OH) D levels were measured. Results No significant differences were observed in maternal age at pregnancy, body mass index (BMI）, ALT, AST, γ-glutamyltransferase levels between two groups (all P > 0.05) . The Apgar scores at 5 minutes of all newborn infants were 10. In the ICP group, the gestational age of pregnant women was younger and the birth weight of newborn infants was lower compared with those in normal group (both P < 0.05) . Serum 25 (OH) D level was (24.84±1.88）μg/L in the ICP group, lower than (31.72±2.39）μg/L in the normal group (P < 0.05) . In the ICP group, 25 (OH) D level in the umbilical vein blood was (13.61±1.24）μg/L, lower compared with (21.96±2.69）μg/L in the normal group (P < 0.01) . The 25 (OH) D level in the umbilical vein blood was positively correlated with serum 25 (OH) D level in pregnant women in both groups (normal group： r=0.763, P < 0.001； ICP group：r=0.726, P < 0.001）. In the ICP group, serum 25 (OH) D level was negatively correlated with TBA level in the ICP group (r=-0.692, P < 0.001）. There was no correlation between serum 25 (OH) D and TBA levels in normal pregnant women (P > 0.05) . There was no significant differences in serum total cholesterol and triglyceride levels between two groups (both P > 0.05) . Conclusions The vitamin D levels in serum and umbilical vein blood of pregnant women in the ICP group are lower than those of normal pregnant women, which may be related to high TBA level in ICP patients. For ICP pregnant women, supplemental dose of vitamin D may be appropriately increased to promote intrauterine development. [ABSTRACT FROM AUTHOR]