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Ex vivo measures of LDL oxidative susceptibility predict carotid artery disease
- Source :
-
Atherosclerosis (00219150) . Mar2005, Vol. 179 Issue 1, p147-153. 7p. - Publication Year :
- 2005
-
Abstract
- Abstract: Aim:: The purpose of the study was to assess whether ex vivo measures of low-density lipoprotein (LDL) oxidation improved prediction of carotid artery disease (CAAD) case-control status compared to standard lipid and smoking measures. Methods:: One hundred and forty cases with a high degree of carotid artery stenosis aged 40–83 years and an equal number of controls without stenosis or other vascular disease were matched by censored age within 2 years. Matched logistic regression evaluated the significance of copper-induced oxidative measures with and without covariates. The relationship of LDL oxidation measures with statin use and current smoking was also evaluated. Results:: Logistic regression demonstrated a significant effect of the three correlated measures of oxidative susceptibility (lag time, oxidation rate and maximal rate of oxidation) separately on disease prediction (all p <0.05). These oxidative measures remained significant predictors of case-control status when other cardiovascular disease predictors (age; LDL-C, HDL-C and ApoAI levels; current smoking, ever smoking and pack-years smoked) were jointly considered. This relationship was not attributable to the effects of statin use on LDL oxidation. Conclusions:: Ex vivo measures of oxidation improved the prediction of carotid artery disease status, suggesting that this is an important determinant of atherosclerotic risk in this older population. [Copyright &y& Elsevier]
- Subjects :
- *LIPOPROTEINS
*CAROTID artery diseases
*OXIDATION
*CARDIOVASCULAR diseases
Subjects
Details
- Language :
- English
- ISSN :
- 00219150
- Volume :
- 179
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Atherosclerosis (00219150)
- Publication Type :
- Academic Journal
- Accession number :
- 17411824
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2004.09.015