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Long duration of atrial high‐rate episode is more favorable in predicting ischemic stroke than high CHA2DS2‐VASc score.
- Source :
-
Pacing & Clinical Electrophysiology . Dec2023, Vol. 46 Issue 12, p1635-1642. 8p. - Publication Year :
- 2023
-
Abstract
- Objective: This study aimed to explore the roles of duration and burden of atrial high‐rate episode (AHRE) on ischemic stroke in patients with pacemaker implantation. Methods: Patients with pacemaker implantation for bradycardia from 2013 to 2017 were consecutively enrolled. Data such as gender, age, combined diseases, type of AF, left atrial size, left ventricular size, left ventricular ejection fraction, CHA2DS2‐VASc score, and anticoagulants were collected. The burden and duration of AHRE based on different interval partition were also recorded in detail to evaluate the impacts on ischemic stroke. Cox regression analysis with time‐dependent covariates was conducted. Results: A total of 220 patients with AHRE were enrolled. The average follow‐up time was 48.42 ± 17.20 months. Univariate regression analysis showed that diabetes (p =.024), high CHA2DS2‐VASc score (≥ 2) (p =.021), long mean AHRE burden (p =.011), long maximal AHRE burden (p =.015), long AHRE duration lasting≥48 h (p =.001) or 24 h (p =.001) or 12 h (p =.005) were prone to ischemic stroke. Further multivariate regression analysis showed that long duration of AHRE (≥48 h) (HR 10.77; 95% CI 3.22–55.12; p =.030) were significantly correlated with stroke in patients with paroxysmal AF. There was no significant correlation between the type of AF and stroke (p =.927). Conclusion: The longer duration of AHRE (≥48 h) was more favorable in predicting ischemic stroke than high CHA2DS2‐VASc score (≥2). [ABSTRACT FROM AUTHOR]
- Subjects :
- *STATISTICS
*VENTRICULAR ejection fraction
*CONFIDENCE intervals
*ISCHEMIC stroke
*MULTIPLE regression analysis
*MULTIVARIATE analysis
*ATRIAL fibrillation
*ANTICOAGULANTS
*RISK assessment
*COMPARATIVE studies
*HEART atrium
*TACHYCARDIA
*DESCRIPTIVE statistics
*RESEARCH funding
*CARDIAC pacemakers
*BRADYCARDIA
*PROPORTIONAL hazards models
*DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 01478389
- Volume :
- 46
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Pacing & Clinical Electrophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 174181325
- Full Text :
- https://doi.org/10.1111/pace.14857