Sampled-data output tracking control based on T–S fuzzy model for cancer-tumor-immune systems.

This study investigates the tracking control issue for a cancer-tumor immune nonlinear model, which explains the interaction between cancer cells and the immune system in the body. To achieve this, the nonlinear model is first converted into linear sub-models using the Takagi–Sugeno (T–S) fuzzy methodology. The tracking and control of cancer cell proliferation while preserving immune cells is proposed using a sample-data output tracking control technique. Time-dependent discontinuous Lyapunov Krasovskii functional is recommended based on the improved Wirtinger inequality, this may provide additional information about the sawtooth structure of the sampling interval. Less conservative stability criteria are extracted having the form of linear matrix inequalities (LMIs) in consequence of extended reciprocally convex matrix inequality and Wirtinger-based integral inequality. The proposed approach achieves the stabilization of an augmented time delay system that connects with a given fuzzy nonlinear model and tracking error system. Furthermore, the proposed approach reduces the impact of external disturbances under the H ∞ norm bound. • Nonlinear cancer tumor-immune model with time delays is considered. • T–S fuzzy technique linearizes the nonlinear model. • Sampled-data output tracking controller with delay state information is developed. • A simulation result is provided to exhibit the effectiveness of the theory. [ABSTRACT FROM AUTHOR]