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Ectopic odorant receptors responding to flavor compounds in skin health and disease: Current insights and future perspectives.

Authors :
Ruixuan Geng
Yanan Wang
Jingjing Fang
Yuhan Zhao
Mengjie Li
SeongGook Kang
Kunlun Huang
Tao Tong
Source :
Critical Reviews in Food Science & Nutrition. 2023, Vol. 63 Issue 28, p9392-9408. 17p.
Publication Year :
2023

Abstract

Skin, the largest organ of human body, acts as a barrier to protect body from the external environment and is exposed to a myriad of flavor compounds, especially food- and plant essential oil-derived odorant compounds. Skin cells are known to express various chemosensory receptors, such as transient potential receptors, adenosine triphosphate receptors, taste receptors, and odorant receptors (ORs). We aim to provide a review of this rapidly developing field and discuss latest discoveries related to the skin ORs activated by flavor compounds, their impacts on skin health and disease, odorant ligands interacting with ORs exerting specific biological effects, and the mechanisms involved. ORs are recently found to be expressed in skin tissue and cells, such as keratinocytes, melanocytes, and fibroblasts. To date, several ectopic skin ORs responding to flavor compounds, are involved in different skin biological processes, such as wound healing, hair growth, melanin regulation, pressure stress, skin barrier function, atopic dermatitis, and psoriasis. The recognition of physiological role of skin ORs, combined with the fact that ORs belong to a highly druggable protein family (G protein-coupled receptors), underscores the potential of skin ORs responding to flavor compounds as a novel regulating strategy for skin health and disease. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10408398
Volume :
63
Issue :
28
Database :
Academic Search Index
Journal :
Critical Reviews in Food Science & Nutrition
Publication Type :
Academic Journal
Accession number :
174188633
Full Text :
https://doi.org/10.1080/10408398.2022.2064812