改良版预处理方案的自体造血干细胞移植治疗急性髓系白血病 3例临床观察及文献复习.

Objective To investigate the efficacy and survival effects of cladribine（CLAD） combined with cytarabine and BuCy pretreatment regimen on autologous hematopoietic stem cell transplantation in patients with acute myeloid leukemia.Methods Patients with acute myeloid leukemia with complete remission and negative residual lesions were selected for autologous hematopoietic stem cell transplantation using CLAD combined with cytarabine and BuCy pretreatment regimen, and the therapeutic effect, transplantation complications and prognosis were observed.Results The transplantation complications of three patients were mild and the hematopoietic reconstruction time was early.The continuous remission time of three patients was 25,20,12 months, respectively, and there was still no recurrence.Conclusion For adult patients with acute myeloid leukemia, CLAD combined with cytarabine and BuCy pretreatment regimen can promote implantation, reduce recurrence rate, and improve the overall quality of life of patients. [ABSTRACT FROM AUTHOR]