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Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance.
- Source :
-
OncoImmunology . 2023, Vol. 12 Issue 1, p1-4. 4p. - Publication Year :
- 2023
-
Abstract
- In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BILE acids
*GUT microbiome
*LYMPHOID tissue
*IMMUNE checkpoint proteins
*T cells
Subjects
Details
- Language :
- English
- ISSN :
- 21624011
- Volume :
- 12
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- OncoImmunology
- Publication Type :
- Academic Journal
- Accession number :
- 174235395
- Full Text :
- https://doi.org/10.1080/2162402X.2023.2224672