Back to Search
Start Over
Cell type-specific induction of ferroptosis to boost antitumor immunity.
- Source :
-
OncoImmunology . 2023, Vol. 12 Issue 1, p1-3. 3p. - Publication Year :
- 2023
-
Abstract
- Traditional ferroptosis activators typically suppress antitumor immunity. Our discovery shows that N6F11, a small molecule compound, can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. This breakthrough establishes a safe and effective strategy to enhance ferroptosis-driven antitumor immunity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNITY
*DRUG discovery
*SMALL molecules
*CANCER cells
Subjects
Details
- Language :
- English
- ISSN :
- 21624011
- Volume :
- 12
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- OncoImmunology
- Publication Type :
- Academic Journal
- Accession number :
- 174235449
- Full Text :
- https://doi.org/10.1080/2162402X.2023.2282252