BISPHOSPHONATES IN ORTHOPAEDIC SURGERY.

The article focuses on the use of bisphosphonates in orhtopaedic surgery. Bisphosphonates are the most clinically important class of antiresorptive agents available to treat diseases characterized by osteoclast-mediated bone resorption such as osteoporosis, Paget disease, and tumor-associated bone diseases. Currently, seven bisphosphonates have the approval of the U.S. Food and Drug Administration. The treatment of pediatric disorders such as osteogenesis imperfecta and fibrous dysplasia with bisphoshonates has gained momentum, and initial investigations have demonstrated an accepted safety profile.